Introduction: Osteoporosis is one of the major fundamental causes of fractures in individuals over 50 years old. Preventing the first fragility fracture is the most cost-effective strategy for addressing osteoporosis. Therefore, identifying individuals with a high risk of developing osteoporotic fractures is important to save limited medical resources. The Fracture Risk Assessment Tool (FRAX) has been used globally for assessing fracture risk. However, the accuracy of FRAX still needs to be improved partially because of the differences in race and socioeconomic status among nationalities. Methods: In this study, we evaluated the effectiveness of FRAX in Chinese people. The factors not involved in FRAX were also evaluated for a correlation with osteoporotic fracture risks. Results: Age, smoking status, alcohol intake, family history of osteoporotic fracture, diabetes mellitus type II, Charlson Index, vitamin D intake, calcium intake, muscle strength, modified Barthel Index, the 3-level version of EuroQol five dimensions questionnaire, and bone mineral density demonstrated significant differences between the fracture and control groups. Our results also demonstrated that dual-energy X-ray absorptiometry (DEXA)-diagnosed osteoporosis (T ≤ −2.5) was the independent fracture risk factor. The effects of age, muscle strength, and Charlson Index on DEXA were found to be statistically significant. People old over 60, muscle strength test supine leg lift less than 20 times per minute, aCCI scores greater than or equal to 2, had lower DEXA T values (T ≤ −2.5). Discussion: This work was a single-center study, showed social economic status bias, and featured a limited number of cases. Therefore, multi-center studies are necessary in the future. Conclusions: This study revealed that FRAX should be improved further in combination with other risk factors, including aCCI, calcium intake, and muscle strength.
| Published in | American Journal of Health Research (Volume 9, Issue 5) |
| DOI | 10.11648/j.ajhr.20210905.18 |
| Page(s) | 198-203 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Osteoporosis, Fracture, FRAX, Risk Factor
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APA Style
Xiao Li, Jun Wu, Xiang Li, Ka Li Frankie Leung, Tak Man Wong, et al. (2021). Evaluation of Risk Factors for Primary Fracture in Elderly Patients with Osteoporosis. American Journal of Health Research, 9(5), 198-203. https://doi.org/10.11648/j.ajhr.20210905.18
ACS Style
Xiao Li; Jun Wu; Xiang Li; Ka Li Frankie Leung; Tak Man Wong, et al. Evaluation of Risk Factors for Primary Fracture in Elderly Patients with Osteoporosis. Am. J. Health Res. 2021, 9(5), 198-203. doi: 10.11648/j.ajhr.20210905.18
AMA Style
Xiao Li, Jun Wu, Xiang Li, Ka Li Frankie Leung, Tak Man Wong, et al. Evaluation of Risk Factors for Primary Fracture in Elderly Patients with Osteoporosis. Am J Health Res. 2021;9(5):198-203. doi: 10.11648/j.ajhr.20210905.18
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Download@article{10.11648/j.ajhr.20210905.18,
author = {Xiao Li and Jun Wu and Xiang Li and Ka Li Frankie Leung and Tak Man Wong and Xinshuo Christian Fang},
title = {Evaluation of Risk Factors for Primary Fracture in Elderly Patients with Osteoporosis},
journal = {American Journal of Health Research},
volume = {9},
number = {5},
pages = {198-203},
doi = {10.11648/j.ajhr.20210905.18},
url = {https://doi.org/10.11648/j.ajhr.20210905.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20210905.18},
abstract = {Introduction: Osteoporosis is one of the major fundamental causes of fractures in individuals over 50 years old. Preventing the first fragility fracture is the most cost-effective strategy for addressing osteoporosis. Therefore, identifying individuals with a high risk of developing osteoporotic fractures is important to save limited medical resources. The Fracture Risk Assessment Tool (FRAX) has been used globally for assessing fracture risk. However, the accuracy of FRAX still needs to be improved partially because of the differences in race and socioeconomic status among nationalities. Methods: In this study, we evaluated the effectiveness of FRAX in Chinese people. The factors not involved in FRAX were also evaluated for a correlation with osteoporotic fracture risks. Results: Age, smoking status, alcohol intake, family history of osteoporotic fracture, diabetes mellitus type II, Charlson Index, vitamin D intake, calcium intake, muscle strength, modified Barthel Index, the 3-level version of EuroQol five dimensions questionnaire, and bone mineral density demonstrated significant differences between the fracture and control groups. Our results also demonstrated that dual-energy X-ray absorptiometry (DEXA)-diagnosed osteoporosis (T ≤ −2.5) was the independent fracture risk factor. The effects of age, muscle strength, and Charlson Index on DEXA were found to be statistically significant. People old over 60, muscle strength test supine leg lift less than 20 times per minute, aCCI scores greater than or equal to 2, had lower DEXA T values (T ≤ −2.5). Discussion: This work was a single-center study, showed social economic status bias, and featured a limited number of cases. Therefore, multi-center studies are necessary in the future. Conclusions: This study revealed that FRAX should be improved further in combination with other risk factors, including aCCI, calcium intake, and muscle strength.},
year = {2021}
}
TY - JOUR T1 - Evaluation of Risk Factors for Primary Fracture in Elderly Patients with Osteoporosis AU - Xiao Li AU - Jun Wu AU - Xiang Li AU - Ka Li Frankie Leung AU - Tak Man Wong AU - Xinshuo Christian Fang Y1 - 2021/09/15 PY - 2021 N1 - https://doi.org/10.11648/j.ajhr.20210905.18 DO - 10.11648/j.ajhr.20210905.18 T2 - American Journal of Health Research JF - American Journal of Health Research JO - American Journal of Health Research SP - 198 EP - 203 PB - Science Publishing Group SN - 2330-8796 UR - https://doi.org/10.11648/j.ajhr.20210905.18 AB - Introduction: Osteoporosis is one of the major fundamental causes of fractures in individuals over 50 years old. Preventing the first fragility fracture is the most cost-effective strategy for addressing osteoporosis. Therefore, identifying individuals with a high risk of developing osteoporotic fractures is important to save limited medical resources. The Fracture Risk Assessment Tool (FRAX) has been used globally for assessing fracture risk. However, the accuracy of FRAX still needs to be improved partially because of the differences in race and socioeconomic status among nationalities. Methods: In this study, we evaluated the effectiveness of FRAX in Chinese people. The factors not involved in FRAX were also evaluated for a correlation with osteoporotic fracture risks. Results: Age, smoking status, alcohol intake, family history of osteoporotic fracture, diabetes mellitus type II, Charlson Index, vitamin D intake, calcium intake, muscle strength, modified Barthel Index, the 3-level version of EuroQol five dimensions questionnaire, and bone mineral density demonstrated significant differences between the fracture and control groups. Our results also demonstrated that dual-energy X-ray absorptiometry (DEXA)-diagnosed osteoporosis (T ≤ −2.5) was the independent fracture risk factor. The effects of age, muscle strength, and Charlson Index on DEXA were found to be statistically significant. People old over 60, muscle strength test supine leg lift less than 20 times per minute, aCCI scores greater than or equal to 2, had lower DEXA T values (T ≤ −2.5). Discussion: This work was a single-center study, showed social economic status bias, and featured a limited number of cases. Therefore, multi-center studies are necessary in the future. Conclusions: This study revealed that FRAX should be improved further in combination with other risk factors, including aCCI, calcium intake, and muscle strength. VL - 9 IS - 5 ER -
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