Aim: investigate the implications of HFD induced obesity on the lipid profile in parent rats and their offspring. Methodology: Twenty adult female rats (100 - 150g) were grouped into A and B which received NRC and HFD respectively for 16 weeks. Group B rats with BMI >0.50g/cm2 were considered obese. Adult male Wistar rats fed with NRC were introduced to each group, to ensure mating and pregnancy after feeding. The offspring produced by the rats in each group were divided into two groups of 20 rats each. They were fed with NRC for 12 months. The plasma obtained from the parent and offspring were analysed for lipid profile test. Result: The parent rats fed with HFD had higher Cholesterol, triglyceride and HDL compared with the rats fed with NRC. At 4 and 12 months, the offspring of HFD fed rats had lower triglyceride and LDL compared with offspring of NRC fed rats. The offspring of HFD fed rats had higher HDL compared with the offspring of NRC fed rats at 8 months. Conclusion: if offspring of obese HFD fed rats are placed on NRC throughout their life time, the consequence of maternal obesity on their lipid profile may notmanifest.
| Published in | American Journal of Health Research (Volume 10, Issue 1) |
| DOI | 10.11648/j.ajhr.20221001.12 |
| Page(s) | 8-12 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Obesity, High Fat Diet, Normal Rat Chow, Triglyceride
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APA Style
Oluwadare Joshua Ogundipe, Rufus Ojo Akomolafe, Olaoluwa Sesan Olukiran, Omolola Funke Akinpelu. (2022). Obesity and the Maternal Lipid Profile: Role of Diet in Epigenetic Transfer on the Offspring. American Journal of Health Research, 10(1), 8-12. https://doi.org/10.11648/j.ajhr.20221001.12
ACS Style
Oluwadare Joshua Ogundipe; Rufus Ojo Akomolafe; Olaoluwa Sesan Olukiran; Omolola Funke Akinpelu. Obesity and the Maternal Lipid Profile: Role of Diet in Epigenetic Transfer on the Offspring. Am. J. Health Res. 2022, 10(1), 8-12. doi: 10.11648/j.ajhr.20221001.12
AMA Style
Oluwadare Joshua Ogundipe, Rufus Ojo Akomolafe, Olaoluwa Sesan Olukiran, Omolola Funke Akinpelu. Obesity and the Maternal Lipid Profile: Role of Diet in Epigenetic Transfer on the Offspring. Am J Health Res. 2022;10(1):8-12. doi: 10.11648/j.ajhr.20221001.12
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Download@article{10.11648/j.ajhr.20221001.12,
author = {Oluwadare Joshua Ogundipe and Rufus Ojo Akomolafe and Olaoluwa Sesan Olukiran and Omolola Funke Akinpelu},
title = {Obesity and the Maternal Lipid Profile: Role of Diet in Epigenetic Transfer on the Offspring},
journal = {American Journal of Health Research},
volume = {10},
number = {1},
pages = {8-12},
doi = {10.11648/j.ajhr.20221001.12},
url = {https://doi.org/10.11648/j.ajhr.20221001.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20221001.12},
abstract = {Aim: investigate the implications of HFD induced obesity on the lipid profile in parent rats and their offspring. Methodology: Twenty adult female rats (100 - 150g) were grouped into A and B which received NRC and HFD respectively for 16 weeks. Group B rats with BMI >0.50g/cm2 were considered obese. Adult male Wistar rats fed with NRC were introduced to each group, to ensure mating and pregnancy after feeding. The offspring produced by the rats in each group were divided into two groups of 20 rats each. They were fed with NRC for 12 months. The plasma obtained from the parent and offspring were analysed for lipid profile test. Result: The parent rats fed with HFD had higher Cholesterol, triglyceride and HDL compared with the rats fed with NRC. At 4 and 12 months, the offspring of HFD fed rats had lower triglyceride and LDL compared with offspring of NRC fed rats. The offspring of HFD fed rats had higher HDL compared with the offspring of NRC fed rats at 8 months. Conclusion: if offspring of obese HFD fed rats are placed on NRC throughout their life time, the consequence of maternal obesity on their lipid profile may notmanifest.},
year = {2022}
}
TY - JOUR T1 - Obesity and the Maternal Lipid Profile: Role of Diet in Epigenetic Transfer on the Offspring AU - Oluwadare Joshua Ogundipe AU - Rufus Ojo Akomolafe AU - Olaoluwa Sesan Olukiran AU - Omolola Funke Akinpelu Y1 - 2022/01/28 PY - 2022 N1 - https://doi.org/10.11648/j.ajhr.20221001.12 DO - 10.11648/j.ajhr.20221001.12 T2 - American Journal of Health Research JF - American Journal of Health Research JO - American Journal of Health Research SP - 8 EP - 12 PB - Science Publishing Group SN - 2330-8796 UR - https://doi.org/10.11648/j.ajhr.20221001.12 AB - Aim: investigate the implications of HFD induced obesity on the lipid profile in parent rats and their offspring. Methodology: Twenty adult female rats (100 - 150g) were grouped into A and B which received NRC and HFD respectively for 16 weeks. Group B rats with BMI >0.50g/cm2 were considered obese. Adult male Wistar rats fed with NRC were introduced to each group, to ensure mating and pregnancy after feeding. The offspring produced by the rats in each group were divided into two groups of 20 rats each. They were fed with NRC for 12 months. The plasma obtained from the parent and offspring were analysed for lipid profile test. Result: The parent rats fed with HFD had higher Cholesterol, triglyceride and HDL compared with the rats fed with NRC. At 4 and 12 months, the offspring of HFD fed rats had lower triglyceride and LDL compared with offspring of NRC fed rats. The offspring of HFD fed rats had higher HDL compared with the offspring of NRC fed rats at 8 months. Conclusion: if offspring of obese HFD fed rats are placed on NRC throughout their life time, the consequence of maternal obesity on their lipid profile may notmanifest. VL - 10 IS - 1 ER -
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