Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors

Zhang Shuli; Hou Jianzhang; Li Hongyan; Hou Zhenjiang; Zhang Fengqiao

doi:doi:10.11648/j.ajhr.20231103.13

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Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors

Zhang Shuli, Hou Jianzhang, Li Hongyan, Hou Zhenjiang, Zhang Fengqiao

Published in American Journal of Health Research (Volume 11, Issue 3)

Received: 19 April 2023 Accepted: 30 May 2023 Published: 6 June 2023

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Abstract

The occurrence and development of tumor are closely related to the imbalance of apoptosis and proliferation regulation. Survivin is a newly discovered member of the apoptosis inhibitory protein (IAP) family with a unique structure. It is widely expressed in embryonic and developmental fetal tissues, with low or no expression in normal terminal differentiated adult tissues, while it is highly expressed in the vast majority of malignant tumor tissues. With the rapid development of molecular biology technology, a significant breakthrough has been made in the molecular mechanism of cell apoptosis. With the discovery that Survivin is involved in regulating two basic processes in cell life, namely inhibiting apoptosis and promoting cell proliferation, and playing a role in cell division and angiogenesis. The high expression of Survivin in malignant tumors indicates its important role in tumor production, apoptosis, and proliferation. The alimentary canal is one of the most common sites of human malignant tumors. In recent years, the incidence rate of alimentary canal tumors has been increasing year by year. Because of the early symptoms being not typical, it is easy to miss diagnosis, and most of them have entered the middle and late stages when diagnosed, which is easy to recur and metastasize, with a high fatality rate and serious harm to human health. Therefore, finding ideal tumor biomarkers for early diagnosis and monitoring prognosis is of great value. This article reviews the research progress of apoptosis inhibitor protein Survivin and its application in esophageal cancer, liver cancer and pancreatic cancer.

Published in	American Journal of Health Research (Volume 11, Issue 3)
DOI	10.11648/j.ajhr.20231103.13
Page(s)	84-94
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Apoptosis Suppressor Protein, Survivin, Biological Characteristics, Esophageal Cancer, Liver Cancer, Pancreatic Cancer, Prognosis

References

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APA Style

Zhang Shuli, Hou Jianzhang, Li Hongyan, Hou Zhenjiang, Zhang Fengqiao. (2023). Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors. American Journal of Health Research, 11(3), 84-94. https://doi.org/10.11648/j.ajhr.20231103.13

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ACS Style

Zhang Shuli; Hou Jianzhang; Li Hongyan; Hou Zhenjiang; Zhang Fengqiao. Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors. Am. J. Health Res. 2023, 11(3), 84-94. doi: 10.11648/j.ajhr.20231103.13

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AMA Style

Zhang Shuli, Hou Jianzhang, Li Hongyan, Hou Zhenjiang, Zhang Fengqiao. Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors. Am J Health Res. 2023;11(3):84-94. doi: 10.11648/j.ajhr.20231103.13

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@article{10.11648/j.ajhr.20231103.13,
  author = {Zhang Shuli and Hou Jianzhang and Li Hongyan and Hou Zhenjiang and Zhang Fengqiao},
  title = {Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors},
  journal = {American Journal of Health Research},
  volume = {11},
  number = {3},
  pages = {84-94},
  doi = {10.11648/j.ajhr.20231103.13},
  url = {https://doi.org/10.11648/j.ajhr.20231103.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20231103.13},
  abstract = {The occurrence and development of tumor are closely related to the imbalance of apoptosis and proliferation regulation. Survivin is a newly discovered member of the apoptosis inhibitory protein (IAP) family with a unique structure. It is widely expressed in embryonic and developmental fetal tissues, with low or no expression in normal terminal differentiated adult tissues, while it is highly expressed in the vast majority of malignant tumor tissues. With the rapid development of molecular biology technology, a significant breakthrough has been made in the molecular mechanism of cell apoptosis. With the discovery that Survivin is involved in regulating two basic processes in cell life, namely inhibiting apoptosis and promoting cell proliferation, and playing a role in cell division and angiogenesis. The high expression of Survivin in malignant tumors indicates its important role in tumor production, apoptosis, and proliferation. The alimentary canal is one of the most common sites of human malignant tumors. In recent years, the incidence rate of alimentary canal tumors has been increasing year by year. Because of the early symptoms being not typical, it is easy to miss diagnosis, and most of them have entered the middle and late stages when diagnosed, which is easy to recur and metastasize, with a high fatality rate and serious harm to human health. Therefore, finding ideal tumor biomarkers for early diagnosis and monitoring prognosis is of great value. This article reviews the research progress of apoptosis inhibitor protein Survivin and its application in esophageal cancer, liver cancer and pancreatic cancer.},
 year = {2023}
}

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TY  - JOUR
T1  - Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors
AU  - Zhang Shuli
AU  - Hou Jianzhang
AU  - Li Hongyan
AU  - Hou Zhenjiang
AU  - Zhang Fengqiao
Y1  - 2023/06/06
PY  - 2023
N1  - https://doi.org/10.11648/j.ajhr.20231103.13
DO  - 10.11648/j.ajhr.20231103.13
T2  - American Journal of Health Research
JF  - American Journal of Health Research
JO  - American Journal of Health Research
SP  - 84
EP  - 94
PB  - Science Publishing Group
SN  - 2330-8796
UR  - https://doi.org/10.11648/j.ajhr.20231103.13
AB  - The occurrence and development of tumor are closely related to the imbalance of apoptosis and proliferation regulation. Survivin is a newly discovered member of the apoptosis inhibitory protein (IAP) family with a unique structure. It is widely expressed in embryonic and developmental fetal tissues, with low or no expression in normal terminal differentiated adult tissues, while it is highly expressed in the vast majority of malignant tumor tissues. With the rapid development of molecular biology technology, a significant breakthrough has been made in the molecular mechanism of cell apoptosis. With the discovery that Survivin is involved in regulating two basic processes in cell life, namely inhibiting apoptosis and promoting cell proliferation, and playing a role in cell division and angiogenesis. The high expression of Survivin in malignant tumors indicates its important role in tumor production, apoptosis, and proliferation. The alimentary canal is one of the most common sites of human malignant tumors. In recent years, the incidence rate of alimentary canal tumors has been increasing year by year. Because of the early symptoms being not typical, it is easy to miss diagnosis, and most of them have entered the middle and late stages when diagnosed, which is easy to recur and metastasize, with a high fatality rate and serious harm to human health. Therefore, finding ideal tumor biomarkers for early diagnosis and monitoring prognosis is of great value. This article reviews the research progress of apoptosis inhibitor protein Survivin and its application in esophageal cancer, liver cancer and pancreatic cancer.
VL  - 11
IS  - 3
ER  -

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Author Information

Zhang Shuli

Department of Hepatobiliary and Pancreatic (Minimally Invasive) Surgery, Medical College Cancer District Affiliate to Cangzhou People's Hospital, Cangzhou, China
Hou Jianzhang

Department of Hepatobiliary and Pancreatic (Minimally Invasive) Surgery, Medical College Cancer District Affiliate to Cangzhou People's Hospital, Cangzhou, China
Li Hongyan

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Hou Zhenjiang

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Zhang Fengqiao

Department of Medical Technology, Shijiazhuang Medical College, Shijiazhuang, China

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APA Style

Zhang Shuli, Hou Jianzhang, Li Hongyan, Hou Zhenjiang, Zhang Fengqiao. (2023). Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors. American Journal of Health Research, 11(3), 84-94. https://doi.org/10.11648/j.ajhr.20231103.13

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ACS Style

Zhang Shuli; Hou Jianzhang; Li Hongyan; Hou Zhenjiang; Zhang Fengqiao. Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors. Am. J. Health Res. 2023, 11(3), 84-94. doi: 10.11648/j.ajhr.20231103.13

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AMA Style

Zhang Shuli, Hou Jianzhang, Li Hongyan, Hou Zhenjiang, Zhang Fengqiao. Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors. Am J Health Res. 2023;11(3):84-94. doi: 10.11648/j.ajhr.20231103.13

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@article{10.11648/j.ajhr.20231103.13,
  author = {Zhang Shuli and Hou Jianzhang and Li Hongyan and Hou Zhenjiang and Zhang Fengqiao},
  title = {Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors},
  journal = {American Journal of Health Research},
  volume = {11},
  number = {3},
  pages = {84-94},
  doi = {10.11648/j.ajhr.20231103.13},
  url = {https://doi.org/10.11648/j.ajhr.20231103.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20231103.13},
  abstract = {The occurrence and development of tumor are closely related to the imbalance of apoptosis and proliferation regulation. Survivin is a newly discovered member of the apoptosis inhibitory protein (IAP) family with a unique structure. It is widely expressed in embryonic and developmental fetal tissues, with low or no expression in normal terminal differentiated adult tissues, while it is highly expressed in the vast majority of malignant tumor tissues. With the rapid development of molecular biology technology, a significant breakthrough has been made in the molecular mechanism of cell apoptosis. With the discovery that Survivin is involved in regulating two basic processes in cell life, namely inhibiting apoptosis and promoting cell proliferation, and playing a role in cell division and angiogenesis. The high expression of Survivin in malignant tumors indicates its important role in tumor production, apoptosis, and proliferation. The alimentary canal is one of the most common sites of human malignant tumors. In recent years, the incidence rate of alimentary canal tumors has been increasing year by year. Because of the early symptoms being not typical, it is easy to miss diagnosis, and most of them have entered the middle and late stages when diagnosed, which is easy to recur and metastasize, with a high fatality rate and serious harm to human health. Therefore, finding ideal tumor biomarkers for early diagnosis and monitoring prognosis is of great value. This article reviews the research progress of apoptosis inhibitor protein Survivin and its application in esophageal cancer, liver cancer and pancreatic cancer.},
 year = {2023}
}

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TY  - JOUR
T1  - Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors
AU  - Zhang Shuli
AU  - Hou Jianzhang
AU  - Li Hongyan
AU  - Hou Zhenjiang
AU  - Zhang Fengqiao
Y1  - 2023/06/06
PY  - 2023
N1  - https://doi.org/10.11648/j.ajhr.20231103.13
DO  - 10.11648/j.ajhr.20231103.13
T2  - American Journal of Health Research
JF  - American Journal of Health Research
JO  - American Journal of Health Research
SP  - 84
EP  - 94
PB  - Science Publishing Group
SN  - 2330-8796
UR  - https://doi.org/10.11648/j.ajhr.20231103.13
AB  - The occurrence and development of tumor are closely related to the imbalance of apoptosis and proliferation regulation. Survivin is a newly discovered member of the apoptosis inhibitory protein (IAP) family with a unique structure. It is widely expressed in embryonic and developmental fetal tissues, with low or no expression in normal terminal differentiated adult tissues, while it is highly expressed in the vast majority of malignant tumor tissues. With the rapid development of molecular biology technology, a significant breakthrough has been made in the molecular mechanism of cell apoptosis. With the discovery that Survivin is involved in regulating two basic processes in cell life, namely inhibiting apoptosis and promoting cell proliferation, and playing a role in cell division and angiogenesis. The high expression of Survivin in malignant tumors indicates its important role in tumor production, apoptosis, and proliferation. The alimentary canal is one of the most common sites of human malignant tumors. In recent years, the incidence rate of alimentary canal tumors has been increasing year by year. Because of the early symptoms being not typical, it is easy to miss diagnosis, and most of them have entered the middle and late stages when diagnosed, which is easy to recur and metastasize, with a high fatality rate and serious harm to human health. Therefore, finding ideal tumor biomarkers for early diagnosis and monitoring prognosis is of great value. This article reviews the research progress of apoptosis inhibitor protein Survivin and its application in esophageal cancer, liver cancer and pancreatic cancer.
VL  - 11
IS  - 3
ER  -

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