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Decentralized Clinical Trial Case Study: Five-stage Process for Recruiting and Completing a Site-less Clinical Study in Less Time and Lower Cost than Traditional Methods
Alex Hilderbrand,
Michael Zangrilli,
Mark Stinson
Issue:
Volume 9, Issue 6, December 2021
Pages:
213-217
Received:
25 September 2021
Accepted:
19 October 2021
Published:
28 October 2021
Abstract: Healthcare delivery models have been thrust towards virtual care delivery, including site-less virtual clinical trial recruitment. Digital health technologies give trial participants a choice of participating from the convenience of home rather than traveling to a trial site, which can increase participant engagement and retention. In this case study, a five-stage process is illustrated in which a 1,000-patient virtual clinical trial was completed in just seven months at a cost 30% lower than traditional site-based recruitment. Participants were located, educated, and navigated through a successful multi-step virtual clinical trial for an at-home colon screening test. The locating and screening of patients were conducted via paid social media ads. Next, respondents were contacted by telephone by patient education specialists for additional screening, education, and support. Per protocol, it was confirmed that participants were scheduled for a colonoscopy with their preferred local provider. Finally, sample collection kits were sent to participants home. Overall, the trial achieved a timeline of six months from the first participant to final analysis, followed by dataset review and analysis in just five days. Among the lessons learned was that the trial was more efficiently conducted with the 83bar virtual process than relying on third-party sites and remote investigators to help with the study. Additionally, social media is the best way to find the right patients in the least amount of time.
Abstract: Healthcare delivery models have been thrust towards virtual care delivery, including site-less virtual clinical trial recruitment. Digital health technologies give trial participants a choice of participating from the convenience of home rather than traveling to a trial site, which can increase participant engagement and retention. In this case stu...
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Knowledge and Preventive Practices Regarding Dengue Fever in Nepal
Raju Khanal,
Rewash Thapa,
Madhav Khanal
Issue:
Volume 9, Issue 6, December 2021
Pages:
218-228
Received:
8 October 2021
Accepted:
29 October 2021
Published:
5 November 2021
Abstract: Dengue is an acute infection disease caused by a flavi virus (species Dengue virus of the genus Flavi virus), transmitted by female mosquito aedes mosquito, infection has globally become a major public health concern since the incidence of the dengue fever has increased more than 30-fold over the last decades. The dengue fever has been a most important public health problems since many years and the various outbreak of the dengue cases has been seen time to time. One of the reasons for the increasing and time to time outbreak of the dengue may be the reason of climate change, global warming, lack of knowledge about signs, symptoms, transmission, preventive measure and lack of ignorance or lack of the preventive practice of the dengue fever. Descriptive, cross-sectional study on 192 head of household's was study population residing in Kanchan RM, Rupandehi District. Respondent was selected using Non probability judgmental sampling techniques by face-to-face interview was used. Result shows 58.3% good knowledge and 62% good practice. Knowledge was found to be associated with Age, Types of family, Size of family, educational level and Family suffered from dengue. Preventive practice was found to be associated with the Ever heard from health professional. Study will contribute towards development of appropriate policy strategies at local level that will tackle the problem associated with the knowledge and preventive practice of DF and provide a basis for future research on this area. Inferential analysis shows that there is significant association between the level of knowledge with age, types of family, size of family, educational level and family suffered from dengue and the level of preventive practice was associated with the ever heard from health professional.
Abstract: Dengue is an acute infection disease caused by a flavi virus (species Dengue virus of the genus Flavi virus), transmitted by female mosquito aedes mosquito, infection has globally become a major public health concern since the incidence of the dengue fever has increased more than 30-fold over the last decades. The dengue fever has been a most impor...
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Alcohol and Human Health in Viewpoints of Time
Issue:
Volume 9, Issue 6, December 2021
Pages:
229-237
Received:
22 June 2021
Accepted:
1 September 2021
Published:
27 November 2021
Abstract: Evaluations of the effect of alcohol on human health are as old as alcohol itself. Opinions vary from the favourable, preventive and curative to the opposite, seein alcohol as symbol evil, the scourge of mankind, toxic substance with a malignant effect on all organs. One of the most terrible is that by drinking even the smallest amount of alcohol, several thousand brain cells are destroyed. A creative person becomes a wreck. Seemingly contradictory views may not actually be mutually exclusive. This brings us to the concept of hormesis, which refers to the so – called biphasic effect, whereby a small amount of substance has a positive effect, but higher concentration of the same substance oppositely produced harm. Dosis Sola Facit Venenum - /The dose itself makes the Poison/ Paracelsus 1493-1541. In june 2nd, 1953 Slovakia honoured the coronation of Queen Elizabeth II by donating 50 litres of wine (Klevner- Pinot Gris) from Radošiná a village near to city of Nitra. Relevant committee deemed the wine as excellent and worthy for the royal table on such a special occasion. It was certainly not a poison.
Abstract: Evaluations of the effect of alcohol on human health are as old as alcohol itself. Opinions vary from the favourable, preventive and curative to the opposite, seein alcohol as symbol evil, the scourge of mankind, toxic substance with a malignant effect on all organs. One of the most terrible is that by drinking even the smallest amount of alcohol, ...
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Sleep Quality Among Pregnant Women Amidst COVID-19: Association with Mental Wellbeing and Self-efficacy
Aman Dule,
Zakir Abdu,
Mohammedamin Hajure,
Mustefa Mohammedhussein
Issue:
Volume 9, Issue 6, December 2021
Pages:
238-245
Received:
2 November 2021
Accepted:
22 November 2021
Published:
7 December 2021
Abstract: Background: Currently, corona virus disease has imposed huge global burdens and psychological impacts. Although unpredicted stress from this outbreak resulted in disturbed sleep in general, its effect on sleep among pregnant women is not well explored yet. Thus, the main aim of this study was to explore quality of sleep among pregnant mothers amidst COVID-19 pandemic. Methods: Health facility-based cross-sectional study was carried out from April to May, 2020 among 228 pregnant women. Frequencies and related percentages were calculated for categorical variables, while continuous variables were computed by mean and standard deviation. Chi-square test was conducted and Pearson correlation coefficient (r) was calculated to assess relationship between variables. For statistical significance, p-value<.05 and 95% CI were considered. Results: For study subjects, the mean age was 30.79 (SD±7.57) and 57% of them had reported quality of sleep quality and mean sleep duration was 6.70 hours (SD±1.95). Among all participants, less than one-fifth (44, 19.3%) of them had reported very good subjective sleep quality. Perceived stress, depression and Anxiety have moderate to strong positive association with Pittsburgh Sleep Quality Index score (r=0.36, 0.37 and 0.57 respectively) at significant level. Self-efficacy was moderately linked in negative direction (r=0.32, p<0.001). Conclusion: As our finding revealed, the occurrence of poor quality of sleep was high among pregnant women during the era of COVID-19 and anxiety, depression and stress were identified as contributor factors. Routine assessment of sleep should be considered along with collaboration of antenatal care and psychiatry units.
Abstract: Background: Currently, corona virus disease has imposed huge global burdens and psychological impacts. Although unpredicted stress from this outbreak resulted in disturbed sleep in general, its effect on sleep among pregnant women is not well explored yet. Thus, the main aim of this study was to explore quality of sleep among pregnant mothers amids...
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The Clinician Scientist: How Rehabilitation Fares ―A Scoping Review
Inderjit Kaur,
Xiao Xi Elsa Pang,
Mindy Liang,
Chi Xuan Zhang,
Ashley Turgeon,
Jessica Yeung,
Dina Brooks,
Julie Vaughan-Graham
Issue:
Volume 9, Issue 6, December 2021
Pages:
246-268
Received:
22 November 2021
Accepted:
16 December 2021
Published:
24 December 2021
Abstract: Background: Clinician scientists (CS) play a role in bridging the gap between research and practice. However, the role of a CS is less established for healthcare professionals in rehabilitation in comparison to medicine. Objective: The purpose of this scoping review was to explore different roles and models of a clinician scientist in rehabilitation and compare this to medicine and nursing. Methods: This review was structured according to the Arksey and O’Malley (2005) framework for scoping reviews. A literature search was conducted from the following databases: EMBASE, MEDLINE, AMED and Web of Science; a grey literature search was conducted from MacSphere, ProQuest, Duck DuckGo, and Google. Results: 95 articles met the inclusion criteria with 73 studies in medicine, including nursing, 10 articles from rehabilitation and 12 articles with mixed professions. The main barriers identified for rehabilitation involved time constraints and lack of funding for research, whereas primary facilitators included development of formalized training programs and presence of mentorship programs. Conclusion: The role of the clinician scientist is more established in medicine compared to rehabilitation. There is a need for an established career trajectory accompanied with training programs. Further studies are required to shape the role and development of secure funding models for CS positions.
Abstract: Background: Clinician scientists (CS) play a role in bridging the gap between research and practice. However, the role of a CS is less established for healthcare professionals in rehabilitation in comparison to medicine. Objective: The purpose of this scoping review was to explore different roles and models of a clinician scientist in rehabilitatio...
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